So far, two diseases have successfully been eradicated: smallpox and rinderpest. The last case of smallpox was in 1977, and the last of rinderpest was in 2001.
100 Mind-Blowing Smallpox Facts
Only two diseases have been completely eradicated. These are smallpox and rinderpest. The last naturally occurring outbreak of smallpox was recorded in 1977.